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Lyme Disease Test

This test measures the levels of IgM and IgG antibodies in response to the bacteria that causes Lyme disease.

Collection method

Typically blood (venipuncture)

Test preparation

None

Restrictions

Ages 18+ only; Could vary by provider

Turnaround time

Typically 48-72 hours

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Lyme disease test

Lyme disease is a bacterial infection that is transmitted through the bite of an infected tick. According to the CDC, the most common test used to diagnose Lyme disease is the ELISA (enzyme-linked immunosorbent assay) test, which looks for antibodies to the bacteria that cause Lyme disease.

What kind of testing is used to diagnose lyme disease?

The testing used to diagnose Lyme disease typically involves blood tests that look for antibodies against the bacteria that cause the disease. The two most common blood tests that are currently used are the enzyme immunoassay (EIA) and the Western blot test, according to the National Library of Medicine (NLM). Both of these tests require a sample of blood.

There are rare cases when a provider may find it necessary to test for lyme disease using a sample of cerebrospinal fluid. This is usually recommended when symptoms affecting the nervous system are present, according to the NLM.

Can lyme disease be diagnosed without a blood test?

According to the Lyme and Tick-Borne Diseases Research Center at Columbia University Irving Medical Center, lyme disease diagnoses’ are made with a combination of a physical exam, past history, and blood testing. In some cases, a diagnosis can be made based on physical examination alone. This usually happens if obvious signs and symptoms of lyme disease are present after a known tick bite in areas where lyme disease is known.

When should I get tested for lyme disease?

You should consider getting tested for Lyme disease if you have been bitten by a tick or if you have been in an area where lyme disease is common and you develop symptoms of lyme disease.

It is important to note that testing for Lyme disease is most accurate several weeks after infection, according to John Hopkins University. This is because it takes time for the body to produce antibodies.

If you are tested too soon after a tick bite, you may get a false negative result. For this reason, your healthcare provider may recommend repeating testing several weeks after the initial test if Lyme disease is still suspected.

What to expect when you get tested for lyme disease

For a blood test, a healthcare provider will use a small needle to gain access to a vein in your arm or hand. They will draw a small sample of blood this way, which will then be tested for lyme disease antibodies.

If nervous system symptoms, like a stiff neck or numbness of the hands or feet, are present your doctor may recommend a CSF test instead of a blood test. For this procedure, a healthcare provider will conduct a sterile procedure called a lumbar puncture or spinal tap. An area of the back is numbed with a numbing agent, and then a needle is passed between two vertebrae in the lower spine. A small sample of cerebrospinal fluid is taken and then sent to a laboratory for testing.

Preparing for a lyme disease test

There are no special instructions for preparing for a lyme disease test, according to the NLM.

What happens when you test positive for lyme disease

If you receive a positive test result for lyme disease, the CDC recommends a second test be done for confirmation. If two positive results are acquired, treatment for an active infection is recommended. Treatment, according to the CDC, includes antibiotics. The most recommended antibiotics are:

  • Doxycycline
  • Amoxicillin
  • Cefuroxime

Finding a lyme disease test

You can find and book a lyme disease test at most healthcare facilities, including:

Can I test for lyme disease at home?

There are at-home tests available for lyme disease, however, it is important to note that these tests may be less accurate than medical-grade testing. It is also possible that you could receive a negative result if you test too early. If you are experiencing symptoms of lyme disease or you are worried that you may have lyme disease, you should speak with a medical provider.

Cost of lyme disease testing

The cost of lyme disease testing will vary depending on your location, your testing facility, and your insurance coverage. According to FindLabTest.com, the current national average of lyme disease tests in the United States is between $135 and $799.

More about lyme disease

What is lyme disease

Lyme disease is a bacterial infection caused by the bacteria borrelia burgdorferi. This bacteria is commonly transmitted by ticks, according to the CDC. In the United States, the CDC reports over 300,000 new cases each year.

Lyme disease has the potential of causing neurological and heart problems if left untreated. Additionally, around 60% of untreated cases will develop lyme arthritis, according to John Hopkins University.

How is lyme disease transmitted?

It is only possible to get lyme disease from a tick bite, according to the CDC. You cannot get lyme disease from any other insect, from an infected person, or from food or water.

Typically, a tick will need to be attached to you for 36 to 48 hours before it can give you lyme disease, according to the NLM.

Where is lyme disease most common?

Lyme disease can be anywhere, at any time. However, it is most prevalent between the months of April through October, according to John Hopkins University.

John Hopkins University also notes that the most common areas for lyme disease in the United States are:

  • The Northeast
  • Upper Midwest
  • Mid-Atlantic
  • Northwestern states, including the Pacific coast, especially northern California

Lyme disease symptoms to watch out for

The most common symptoms of lyme disease, as outlined by the CDC, are:

  • Fever
  • Fatigue
  • Headache
  • Muscle or joint aches
  • A rash that looks like a bull’s-eye

It's important to note that not everyone with Lyme disease develops a bull's-eye rash, and some people may not experience any symptoms until weeks or months after the initial tick bite. If you suspect that you may have been exposed to Lyme disease, you should talk to your healthcare provider about whether testing is necessary.

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Lyme Disease Testing FAQs

Find answers to the most commonly asked questions about lab tests.

Lyme disease testing is considered reliable in most cases, according to the CDC and NLM. However, it is possible to receive a false negative result if you are tested too soon. For this reason, the CDC recommends testing over several weeks time for people in areas where cases are prevalent.Additionally, it is possible to get a false positive result if you have previously had lyme disease. In this case, your doctor will use a physical exam and your recent history to determine if you have a current lyme disease infection, according to the Mayo Clinic.
People will not have detectable lyme disease antibodies until 2 to 6 weeks after the tick bite, according to Uptodate.com. For this reason, testing for lyme disease at the time of the tick bite is not reliable, and the CDC recommends testing over several weeks.
The results of a lyme disease test are usually available within 1 to 2 weeks, according to Kaiser Permanente.

This publication is not intended to solicit the purchase of laboratory testing from any individual consumer.

Dr. Rob Rohatsch, MD

Updated on Jan 25, 2023

Medically reviewed by

Dr. Rob Rohatsch, MD
LinkedIn

Dr. Rob Rohatsch currently serves as Chief Medical Officer for Solv Health. Dr. Rohatsch brings his extensive background in multi-site ambulatory medicine operations, on-demand healthcare, and consumerism to Solv, where he helps drive strategic initiatives in a cross functional executive role. He brings comprehensive healthcare expertise ranging from medical group operations to revenue cycle management and clinical expertise.

Dr. Rohatsch completed his military service in the US Air Force and earned his MD from Jefferson Medical College of Thomas Jefferson University. Dr. Rohatsch served on the Yale School of Medicine faculty teaching at the medical school and is currently on faculty at the Haslam School of Business at the University of Tennessee teaching in the Executive MBA Program. He also serves on several boards and chairs The TJ Lobraico Foundation.

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